Number of times cited according to CrossRef: Machine learning on drug-specific data to predict small molecule teratogenicity. Discussion Data Extraction - Truven Health Analytics. Similar trends were found in the full postoperative year, with an estimated 1.18-fold increase (95% CI, 1.04-1.35) in health care expenditures and an increase of 1.15 times (95% CI, 1.08-1.23) the number of health care utilization days compared with laparoscopy. Using data from the MarketScan Health Risk Assessment Database and Commercial Claims and Encounters Database, we identified breast cancer patients who received breast reconstruction surgery following mastectomy between 2009 and 2012. Methods: Data between 1 January 2006 and 31 December 2014 from patients aged 6-17 years in the Truven Health Analytics MarketScan database were used to generate two cohorts of patients: (1) atomoxetine users and (2) stimulant (methylphenidates or amphetamines) users. Among 3496 pregnancy outcomes exposed to sumatriptan in the first trimester in the claims analysis, 5.0% were elective abortions, 18.0% were spontaneous abortions, 0.4% were stillbirths, and 77.7% were livebirth deliveries (Table 3). IBM MarketScan Research Databases at UCSF (formerly Truven Health Analytics Inc.) Data Description . We highlight new opportunities for endophenotype‐informed, drug discovery in AD, by exploiting multi‐omics data. The top associated EHR phenotypes were assessed in combination as a phenotype risk score (PheRS) for discriminating CF case status in an additional 2.8 million patients from Vanderbilt University Medical Center (VUMC) and 125,305 adult patients including 25,314 CF cases from MarketScan, an independent external cohort. Thus, there is a possibility of misidentifying the exact date of triptan exposure, but this should have minimal impact on the accuracy of assignment of trimester of exposure. Patients were tracked for BDI and other complications. Methods: Conclusion Clinically Proven Outcomes. Over the same interval, the proportion of patients with generic warfarin exposure appearing increased significantly, whereas the proportion of patients with branded warfarin exposure decreased significantly. Assuming “sticky” prescription patterns, opportunity exists to improve (current) initial HTN treatments. In claims analysis using the Marketscan database, 5120 pregnancies among 4797 distinct women were included in the study cohorts (Figure 1). BACKGROUND In primary care, only ultrasound is more frequently ordered in those <65 years. During the 12‐month period prior to the pregnancy episode, 25.7% of sumatriptan‐exposed women had dispensing of nonsteroidal anti‐inflammatory agents while 49.2% had dispensing of opioids. Purpose. The Truven Medicare database contains the healthcare experience of individuals with Medicare supplemental insurance paid for by employers. The mean (SD) net and total payments were lower for laparoscopy ($23 064 [$14 558] and $24 196 [$14 507] vs $29 753 [$21 421] and $31 606 [$23 586]). This database contains deidentified information on geographically diverse, commercially insured patients in the United States. Materials and Methods Conversely, pregnant patients may take medication during pregnancy that was obtained from a prescription written and dispensed prior to the conception date. These results confirm broad agreement between the database analysis and the registry regarding the safety of triptans during pregnancy. Linked infants were required to have 12‐month continuous insurance enrolment beginning from the delivery date. Author information: (1)Eli Lilly and Company, Indianapolis, IN, USA. The IBM® MarketScan® Research Databases are one of the largest proprietary collections of de-identified US patient data available for healthcare research. We examined and compared, over the same time frame, the outcomes of triptan exposure in pregnancy using (1) a retrospective claims database and (2) a previously completed pregnancy registry. Objective: Purpose. The study population for the claims analysis was drawn from administrative claims data contained in the Truven Health Marketscan Commercial Claims and Encounters and Medicare Supplemental and Coordination of Benefits Databases for the period of 1996 to 2012. Hence, individuals included in the database are covered under private insurance plans; no Medicaid or … Those >80 years had a significantly higher proportion of iron testing and abdominal XR requested in hospital. The prevalence of obesity was similar: 42.1% and 39.6%, with similar age and female distribution (41.5% and 41.1%) but different male distribution (42.7% and 37.9%). We estimate the burden of GI disease in the United States. It contains complete information on inpatient prescriptions, as well as links to outpatient prescription data. We described a novel approach to summarize clinical manifestations from patient EHRs into phenotypic evidence for cystic fibrosis (CF) with potential to alert unrecognized patients of the disease. Among live‐born infants linked to birth mothers, the frequency of major birth defects was determined overall and stratified by earliest trimester of exposure to sumatriptan, naratriptan, and sumatriptan/naproxen sodium. No differences were found regarding perception of symptom seriousness and symptom disclosure between age groups as no longer duration to diagnosis or treatment was observed in the oldest groups. The Truven Health MarketScan® database was selected because it is considered the gold standard in proprietary US healthcare databases, containing real-world data for healthcare research and analytics. Overall, there was broad agreement between the findings of the claims analysis and the registry. (Preprint), Electronic health record phenotypes associated with genetically regulated expression of CFTR and application to cystic fibrosis, Temporal trend in the use of hysteroscopic vs laparoscopic sterilization and the characteristics of commercially insured and Medicaid-insured females in the US who have had the procedures, Effect of Laparoscopic Surgery on Health Care Utilization and Costs in Patients Who Undergo Colectomy, Burden of Gastrointestinal Disease in the United States: 2012 Update, Clinical and economic impact of infusion reactions in patients with colorectal cancer treated with cetuximab, Medical and Surgical Treatment of Parathyroid Diseases: An Evidence-Based Approach, Association of Preoperative Anti–Tumor Necrosis Factor Therapy With Adverse Postoperative Outcomes in Patients Undergoing Abdominal Surgery for Ulcerative Colitis, A comparison of patient-centered economic and clinical outcomes of post-mastectomy breast reconstruction between obese and non-obese patients, Costs of HPB surgery and readmissions in privately-insured US patients, Metformin for Primary Colorectal Cancer Prevention in Patients With Diabetes: A Case-Control Study in a US Population, Age differences in presentation, diagnosis pathway and management of colorectal cancer, Completeness of prescription information in US commercial claims databases, A claims-based Markov model for Crohn's disease. The increasing use of electronic health records (EHRs) and biobanks offers unique opportunities to study Mendelian diseases. Marketscan Commercial Claims and Encounters and Medicare Supplemental Databases; Overview of data contents. Using a large US commercial insurance database, we examined the completeness of warfarin prescription claims among patients with atrial fibrillation receiving regular medical follow-up and testing to manage warfarin dosing. A total of 6,060 publicly insured CCHC from the 2004-2009 Medical Expenditure Panel Surveys were analyzed using negative binomial models to, Access scientific knowledge from anywhere. However, the number of visits for males was significantly higher in the CEMR (CEMR: 270.8 and NAMCS: 239.0). There were 40 063 patients identified, with a total of 420 773 cycles [remission (197 111; 46.8%), mild-moderate (44 024; 10.5%), moderate-severe (132 695; 31.5%), severe-fulminant (46 925; 11.2%)]. Data S1: Appendix S1: Migraine case finding algorithm in the Marketscan database. The authors wish to acknowledge the contributions of the following colleagues from Amgen Inc.: Michael Gruber and Sarah Marshall for their assistance with the study analysis. Truven Health Analytics, an IBM Company Truven Health MarketScan® Research Databases All Truven Health MarketScan® Research Database projects are subject to a data use agreement. Data about individual patients are integrated from all providers of care, maintaining all healthcare utilization and cost record connections at the patient level. Outcomes included 90-day complications, emergency department visits, and readmissions. Of 25 481 patients who underwent colectomy, 4160 were included in the study (laparoscopic, 45.6%; open, 54.4%). METHODS Data Source. To date, the primary approach to post‐approval safety data collection and evaluation in pregnant women has been the prospective exposure registry.2, Prospective exposure registries are observational studies in which pregnant women exposed to a specified medication are enrolled for the purpose of actively collecting information about the exposure and specified associated outcomes.1 These registries are intended to generate robust safety data that can contribute to understanding of risk‐benefit of medications and guide clinical practice as it relates to use of medications in pregnancy. Conclusions. The Truven Health MarketScan Commercial Claims and Encounters and Medicare Supplemental databases are US-based administrative claims databases. Ann Arbor, MI: Truven Health Analytics Inc.; 2015, Using MarketScan Data for Health Economic Modeling Studies, Miller J. These claims data are collected from several hundred insurance providers, … The proportion of infants with major birth defects would thus be underestimated in the database study relative to the registry. Conclusions: Transition probabilities were calculated from consecutive 6-month periods. The objectives of this study were to compare, by patient obesity status, the contemporary utilization patterns of different reconstruction surgery types, understand postoperative complication profiles in the community setting, and analyze the financial impact on health care payers and patients. Truven, and to a lesser extent Symphony, do not capture all Medicare and Medicaid enrollees. The total cost for outpatient GI endoscopy examinations was $32.4 billion. The Cochran-Armitage test was used to evaluate the utilization pattern of breast reconstruction surgery. In univariate analyses, increased postoperative complications were observed among patients in the ileal pouch cohort who received anti-TNF agents preoperatively vs those who did not (137 [45.2%] vs 327 [37.6%]; P = .02) but not among those in the colectomy or proctocolectomy cohorts. Conclusion The University of North Carolina Chapel Hill, through The North Carolina Translational and Clinical Sciences Institute (NC TraCS), holds an annually renewable license for the IBM® MarketScan® Commercial Claims and Encounters and Medicare Supplemental Databases for the years 2000 through 2018. Using the Marketscan database, the risk of major birth defects was ascertained in live‐born infants whose birth mothers were exposed to sumatriptan, naratriptan, or sumatriptan/naproxen during pregnancy. Patients without confirmed laterality and patients that underwent concomitant ligament reconstruction were excluded. Results The MarketScan Commercial Claims and Encounters Database is a research database owned by Truven Health Analytics. Around 75% of migraine patients are women, and the prevalence of migraine is the highest for ages 20 to 50 years, when women are of reproductive age.7 Pharmacologic treatment of migraine during pregnancy is typically focused on acute medications, and sporadic use of triptans after the first trimester may be considered. Corresponding author for the management of gout, they are not consistent in gout patients further. Procedure Coding System codes Databases include the Kaiser Permanente clinical research Networks and by! The occurrence of outcomes observed were compared with the NAMCS and the registry were very small AD may challenge reductionist... Features more than 264 million covered individuals, 37 billion Service records, more than 160 contributing …. Cancer in the short- and long-term Health care costs for patients with at least year. 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